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9.2 Installing Bioperl



Installing Bioperl's
large collection of modules isn't too difficult. It
usually goes fairly painlessly, even though there are a few extra
installation steps due to the additional outside programs and Perl
modules on which Bioperl depends. You will probably want to use
Perl's CPAN to fetch and install Bioperl.


INSTALL is a good document that covers Bioperl
installation on Unix/Linux, Windows, and Mac operating systems.
It's part of the Bioperl distribution and is located
at http://bioperl.org/Core/Latest/INSTALL. This
location may change, but it's easy to find from the
Download link on the main Bioperl web page. If
you're going to install Bioperl, I recommend you
read this document first; here, I'll give an
overview of what's available and add a few
additional comments that may help with installation.


Here's how to get Bioperl on different platforms:



On Unix/Linux, if you download the tar file from
the web site, you merely need to untar it and go through the
configure and make process by hand, as described in the
INSTALL file that comes with the distribution.



If you have a Microsoft Windows machine with
ActiveState's Perl (http://www.activestate.com),
there's a PPM file available for Bioperl; at the
time of this writing, it's at http://bioperl.org/ftp/DIST/Bioperl-1.2.1.ppd.



There is also a CVS repository for Bioperl from which you can fetch
the most current versions of the modules. But be careful: some newer
versions of the modules are implementing new features and have more
bugs than are found in some of the older, more stable releases. The
details of how to install from CVS are also available at the Bioperl
web page.




All these methods for installing Bioperl are fine, but probably the
most common way for Perl programmers to install sets of modules is by
way of CPAN. I discussed CPAN in Chapter 1, but it's
worth discussing again as it relates to Bioperl.


To install Bioperl, you start by typing the following at the command
line:


perl -MCPAN -e shell;


This gives the CPAN shell prompt:


cpan>


It's often the case that a module you want to
install may require other modules for its proper operation, and
perhaps one or more of these additional modules have not yet been
installed. The CPAN system includes a way to check to see what other
modules are required, and you can configure it to automatically
follow and install missing prerequisites.


Especially with a large collection of modules like Bioperl, you may
expect to see such prerequisites crop up. When I asked my CPAN
session how it was configured:


cpan> o conf


one of the lines of output from that query was:


prerequisites_policy ask


I couldn't find a way to list the options within my
CPAN session, so I took a look at the CPAN documentation in another
window with perldoc CPAN,
searched for the string prerequisites_policy, and
read the following:


prerequisites_policy
what to do if you are missing module prerequisites
('follow' automatically, 'ask' me, or 'ignore')


To handle the prerequisites automatically, I configured my CPAN
session like so:


cpan> o conf prerequisites_policy follow


Now, if you have a slow Internet connection, setting the option this
way can be a problem, because some prerequisites may take a long time
to install, and you'll be stuck waiting for
everything to finish. In that case, you may prefer to be asked about
each prerequisite, so you can see if you have the needed time to do
the installation. Plan on the process taking at least a couple of
hours. My experience using both a dial-up modem and a cable modem
from a home office is that the time involved was not too onerous.


As you probably know by now, you can see a summary of CPAN session
commands by typing help:


cpan> help
Display Information
command argument description
a,b,d,m WORD or /REGEXP/ about authors, bundles, distributions, modules
i WORD or /REGEXP/ about anything of above
r NONE reinstall recommendations
ls AUTHOR about files in the author's directory
Download, Test, Make, Install...
get download
make make (implies get)
test MODULES, make test (implies make)
install DISTS, BUNDLES make install (implies test)
clean make clean
look open subshell in these dists' directories
readme display these dists' README files
Other
h,? display this menu ! perl-code eval a perl command
o conf [opt] set and query options q quit the cpan shell
reload cpan load CPAN.pm again reload index load newer indices
autobundle Snapshot force cmd unconditionally do cmd
cpan>


To find the Bioperl distribution, I typed:


cpan> i /bioperl/


and got the following output:


cpan> i /bioperl/
CPAN: Storable loaded ok
Going to read /root/.cpan/Metadata
Database was generated on Sun, 27 Apr 2003 04:12:50 GMT
Bundle Bundle::BioPerl (C/CR/CRAFFI/Bundle-BioPerl-2.04.tar.gz)
Distribution B/BI/BIRNEY/bioperl-0.05.1.tar.gz
Distribution B/BI/BIRNEY/bioperl-0.6.2.tar.gz
Distribution B/BI/BIRNEY/bioperl-0.7.0.tar.gz
Distribution B/BI/BIRNEY/bioperl-1.0.2.tar.gz
Distribution B/BI/BIRNEY/bioperl-1.0.tar.gz
Distribution B/BI/BIRNEY/bioperl-1.2.1.tar.gz
Distribution B/BI/BIRNEY/bioperl-1.2.tar.gz
Distribution B/BI/BIRNEY/bioperl-db-0.1.tar.gz
Distribution B/BI/BIRNEY/bioperl-ext-0.6.tar.gz
Distribution B/BI/BIRNEY/bioperl-gui-0.7.tar.gz
Distribution C/CR/CRAFFI/Bundle-BioPerl-2.04.tar.gz
Module Bio::LiveSeq::IO::BioPerl (B/BI/BIRNEY/bioperl-1.2.1.tar.gz)
13 items found
cpan>


From looking at the Bioperl web page, I knew that the
Bundle::BioPerl had extra useful modules in it
that Bioperl uses.


I started the installation by first installing the
Bundle:


cpan> install Bundle::BioPerl


This process fetched the module code from a CPAN repository, unpacked
it, tested it, and installed it, including its prerequisites (without
questions asked because I set the follow option as
described earlier in this section).


Somewhat fortified by my success, I decided to go for broke and
install the main Bioperl distribution.


From the search output from my CPAN query, i
/bioperl/
, just shown, I saw that the highest numbered
release was 1.2.1. Just to be sure it was the latest release, I also
spent some time at the Bioperl web site reading the news about the
latest releases, so I was quite sure it was what I wanted.


I also spent some time reading the INSTALL file,
and I knew that I was generally in good shape. I had a new-enough
version of Perl (Version 5.8.0) and was on one of the standard
supported platforms.


I installed it on a notebook computer with an Intel 686 processor
that had the RedHat Linux 7.2 operating system. The computer and the
operating system were about two years old, old enough that I did do
some looking around on the Bioperl web site to see if there were any
advisories about which versions of Linux were recommended or advised
against.


In general, modern computer systems are complex, and they change
rapidly. Operating systems and hardware have a replacement cycle of
about two years. Some of this is planned obsolescence; some is
legitimate technical progress. Whatever the cause, the result is that
a system such as the one I'm describing needs
several pieces to be in sync. The hardware, operating system
software, Perl version, and Bioperl version have to coexist; other
pieces such as the C compiler, web browser, web server, and so forth
may also cause problems. Hence my interest in checking to see if
there were any advisories on these topics.


However, I didn't see any warnings about my
particular platform. And since I had recently installed the latest
version of Perl with success, I felt I had performed due diligence
and that I should go ahead and try to install the Bioperl modules.


To do so, I typed:


cpan> install B/BI/BIRNEY/bioperl-1.2.1.tar.gz


There followed a great amount of activity as CPAN got the
distribution from the Internet and tested the various modules. After
a time, the tests were complete; a few of them had failed, and CPAN
decided not to install the modules. Since only a handful of module
tests failed, I looked at the output on my screen and decided that
the failures were only in peripheral parts of Bioperl I
didn't have an immediate use for, and if I ever did
need them, I could fix them later.


So, to finish the installation, I forced CPAN to do the installation
despite the presence of some test failures:


cpan> force install B/BI/BIRNEY/bioperl-1.2.1.tar.gz


This resulted in the modules and the documentation being
installed.



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